Why the study?
Does manipulation of blood pressure or viscosity reveal a relationship between cardiac output and cerebral blood flow in severely head-injured patients?
Population
35 comatose patients with severe head injury and no history of cardiac disease.
Comparison
Manipulation of blood pressure with… vs Baseline measurements before drug administration.
Design
Other
Authors
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Cardiac output changes should not guide cerebral perfusion targets in head injury; hypothesis-generating for viscosity reduction as mannitol's mechanism when autoregulation fails.
Does manipulation of blood pressure or viscosity reveal a relationship between cardiac output and cerebral blood flow in severely head-injured patients?
Changes in cerebral blood flow are not related to cardiac output even when autoregulation is impaired, suggesting that the effect of intravascular volume expansion is mediated by decreased blood viscosity rather than cardiac output augmentation.
Bouma et al. (1990) studied this question.
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