Key result
On a weight basis, IFNβ-1a sc formulations (new and original) demonstrated significantly higher antiviral activity and induced higher levels of ISG mRNA compared to IFNβ-1b sc.
Why the study?
Does interferon beta-1a subcutaneous new formulation maintain antiviral and ISG activities compared to the original formulation and interferon beta-1b in an in vitro model?
Does interferon beta-1a subcutaneous new formulation maintain antiviral and ISG activities compared to the original formulation and interferon beta-1b in an in vitro model?
The new formulation of subcutaneous interferon beta-1a demonstrates comparable in vitro biologic activity to the original formulation and greater activity per weight than interferon beta-1b.
New IFNβ-1a sc formulation maintains in vitro activity equivalent to original; leaves open clinical relevance versus IFNβ-1b.
A new formulation (NF) of subcutaneous (sc) interferon (IFN) β-1a was developed in an attempt to improve injection tolerability and immunogenicity. We compared antiviral and IFNβ-stimulated gene (ISG) activities of IFNβ-1a sc NF with IFNβ-1a sc original formulation and IFNβ-1b sc. When equivalent unit amounts were compared, the IFNβ formulations demonstrated similar antiviral activity and induced similar levels of ISG mRNA. However, on a weight basis (ng/mL), significantly more IFNβ-1b sc was needed to equal the antiviral activity of either IFNβ-1a sc formulation, and both IFNβ-1a sc formulations induced significantly higher levels of ISG mRNA than IFNβ-1b sc.
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Scagnolari et al. (2013) studied Relapsing Multiple Sclerosis. IFNβ-1a sc new formulation (NF) vs. IFNβ-1a sc original formulation and IFNβ-1b sc was evaluated on Antiviral and IFNβ-stimulated gene (ISG) activities. On a weight basis, IFNβ-1a sc formulations (new and original) demonstrated significantly higher antiviral activity and induced higher levels of ISG mRNA compared to IFNβ-1b sc.
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