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September 27, 2010Journal of Interferon & Cytokine Research

Critical Review: Assessment of Interferon-β Immunogenicity in Multiple Sclerosis

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Key result

This review highlights pitfalls in assays for detecting anti-interferon antibodies in multiple sclerosis and emphasizes the need for individualized medicine over standardized regimens.

Population

Patients with multiple sclerosis treated with human recombinant interferon-beta

Design

Review

Authors

KBKlaus Bendtzen

Discussion

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Overview

Assay pitfalls warrant cautious interpretation of anti-interferon antibodies in MS; leaves open optimal individualized regimens pending validation.

Structured PICO

P
Population
Patients with multiple sclerosis treated with human recombinant interferon-beta
I
Intervention
Human recombinant interferon-beta
O
Outcome
Detection of anti-interferon antibodies (binding and neutralizing)

This review emphasizes the complexities of detecting anti-interferon antibodies in multiple sclerosis and advocates for individualized therapeutic approaches.

Cite This Study

Klaus Bendtzen (2010) conducted a review in Multiple Sclerosis. Human recombinant IFN-β was evaluated. This review highlights pitfalls in assays for detecting anti-interferon antibodies in multiple sclerosis and emphasizes the need for individualized medicine over standardized regimens.

synapsesocial.com/papers/6a830bfdb2f729353b1f2525https://doi.org/10.1089/jir.2010.0091
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Neutralizing antibodies to interferon beta: implications for the management of multiple sclerosis2004 · 42 citations
  2. 2Injecting rationale into interferon-β therapy2000 · 5 citations
  3. 3Immunogenic effects of recombinant interferon-beta therapy disrupt the JAK/STAT pathway in primary immune cells from patients with multiple sclerosis2012 · 8 citations
  4. 4Measuring and management of Anti-Interferon Beta Antibodies in subjects with Multiple Sclerosis2007 · 43 citations
  5. 5Single-Nucleotide Polymorphisms in Response to Interferon-Beta Therapy in Multiple Sclerosis2010 · 17 citations