Why the study?
Does non-culprit coronary artery PCI at the time of primary PCI improve 90-day outcomes in STEMI patients with multi-vessel disease?
Population
2,201 ST-elevation myocardial infarction patients with multi-vessel coronary artery disease undergoing…
Comparison
Non-infarct-related arteries PCI performed at… vs PCI of the infarct-related artery (IRA) alone
Design
Cohort
Follow-up
90 days
Key result
Non-culprit coronary intervention during primary PCI was associated with an increased hazard of 90-day mortality compared to infarct-related artery PCI alone (adjusted HR 2.44; 95% CI 1.55-3.83; P<0.001).
Authors
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May increase 90-day mortality risk with non-culprit PCI at primary PCI; leaves open confirmation in randomized trials.
Observational (n=2,201)
Does non-culprit coronary artery PCI at the time of primary PCI improve 90-day outcomes in STEMI patients with multi-vessel disease?
Hazard Ratio: 2.44 (95% CI 1.55–3.83)
Absolute Event Rate: 12.5% vs 5.6%
p-value: p=< 0.001
Performing non-culprit PCI at the time of primary PCI in STEMI patients with multi-vessel disease is associated with significantly increased 90-day mortality.
Toma et al. (2010) conducted an observational in ST-elevation myocardial infarction with multi-vessel coronary artery disease (n=2,201). Non-culprit coronary artery percutaneous coronary intervention (non-IRA PCI) vs. PCI of the infarct-related artery (IRA) alone was evaluated on 90-day mortality (adjusted HR 2.44, 95% CI 1.55-3.83, p=< 0.001). Non-culprit coronary intervention during primary PCI was associated with an increased hazard of 90-day mortality compared to infarct-related artery PCI alone (adjusted HR 2.44; 95% CI 1.55-3.83; P<0.001).