Key result
Serum NGAL predicted contrast-induced acute kidney injury after elective PCI with a sensitivity of 95.8% and specificity of 97.6% at a cut-off value of 118 μg/L.
Why the study?
Does serum NGAL provide an early and better diagnostic biomarker than serum creatinine for acute kidney injury after percutaneous coronary intervention?
Observational (n=151)
Does serum NGAL provide an early and better diagnostic biomarker than serum creatinine for acute kidney injury after percutaneous coronary intervention?
Serum NGAL is a highly sensitive and specific early biomarker for predicting contrast-induced acute kidney injury following elective PCI.
Objectives This study was designed to find the reliability of serum NGAL as an early and better diagnostic biomarker than that of serum creatinine for acute kidney injury after percutaneous coronary intervention in Pakistani population. Materials and methods One hundred and fifty-one patients undergoing elective percutaneous coronary intervention were included and demographic data were recorded. Blood was drawn by venipuncture in clot activator vacutainers and serum was separated and stored at 4°C. Sample was drawn before the percutaneous procedure and subsequently sampling was done serially for 5 days. Results The mean±SD serum NGAL pre-PCI (39.92± 10.35 μg/L) and 4 h post-PCI (100.42±26.07 μg/L) showed highly significant difference (p<0.001). The mean±SD serum creatinine pre-PCI (70.1±11.8 μmol/L) and post-PCI (71.2±11.6 μmol/L) showed significant difference (p=0.005) on day 2 onwards but mean microalbumin showed insignificant results (p=0.533). The serum NGAL predicted CI-AKI with sensitivity of 95.8% and specificity of 97.6% for a cut off value of 118 μg/L. Conclusion Our results suggest that NGAL is an excellent early diagnostic biomarker for acute kidney injury in patients undergoing elective percutaneous coronary intervention.
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Choudhry et al. (2017) conducted an observational in Acute kidney injury after percutaneous coronary intervention (n=151). Serum NGAL vs. Serum creatinine was evaluated on Prediction of contrast-induced acute kidney injury (CI-AKI). Serum NGAL predicted contrast-induced acute kidney injury after elective PCI with a sensitivity of 95.8% and specificity of 97.6% at a cut-off value of 118 μg/L.
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