Key result
Salivirus/klassevirus was detected in 4.2% of fecal samples from children with diarrhea compared to 0% in healthy controls, demonstrating a significant association with diarrhea (p=0.03).
Why the study?
Is salivirus/klassevirus infection associated with diarrhea in children?
Case-Control (n=312)
Yes
Is salivirus/klassevirus infection associated with diarrhea in children?
Absolute Event Rate: 4.2% vs 0%
p-value: p=0.03
Salivirus/klassevirus is present in and significantly associated with pediatric diarrhea in China, expanding the known geographic distribution of this newly characterized virus.
Supports potential etiologic role in pediatric diarrhea; leaves open causality and need for prospective confirmation.
To learn more about salivirus/klassevirus, we tested feces of children with diarrhea in China during 2008-2009. We isolated the virus from 9/216 diarrhea samples and 0/96 control samples. The nearly full polyprotein of 1 isolate, SH1, showed 95% identity with a salivirus from Nigeria, indicating widespread distribution and association with diarrhea.
No takes yet. Share an insight, caveat, or question.
Shan et al. (2010) conducted a case-control in Diarrhea (n=312). Salivirus/Klassevirus vs. Healthy controls was evaluated on Detection of salivirus/klassevirus (p=0.03). Salivirus/klassevirus was detected in 4.2% of fecal samples from children with diarrhea compared to 0% in healthy controls, demonstrating a significant association with diarrhea (p=0.03).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: