Key result
β-Hydroxybutyrate significantly restored doxorubicin-induced left ventricular dysfunction and partially prevented adverse cardiac remodeling by inhibiting cell apoptosis and oxidative stress.
Why the study?
Doxorubicin is limited by serious irreversible cardiotoxicity, and whether beta-hydroxybutyrate can protect against doxorubicin-induced cardiotoxicity remains unknown.
Does β-Hydroxybutyrate prevent doxorubicin-induced cardiotoxicity in mice and cardiomyocytes?
Population
C57BL/6 mice and H9c2 cardiomyocytes
Comparison
Sham vs doxorubicin vs doxorubicin plus beta-hydroxybutyrate
Design
Randomized preclinical animal and in vitro study
Authors
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BHB may attenuate doxorubicin cardiotoxicity in mice; leaves open translation to human cardioprotection.
Does β-Hydroxybutyrate prevent doxorubicin-induced cardiotoxicity in mice and cardiomyocytes?
p-value: p=<0.01
BHB protects against doxorubicin-induced cardiotoxicity by inhibiting oxidative stress and apoptosis, highlighting its potential as a cardioprotective metabolite.
Liu et al. (2021) studied Doxorubicin-induced cardiotoxicity (n=18). β-Hydroxybutyrate vs. Doxorubicin alone was evaluated on Ejection fraction (EF) (p=<0.01). β-Hydroxybutyrate significantly restored doxorubicin-induced left ventricular dysfunction and partially prevented adverse cardiac remodeling by inhibiting cell apoptosis and oxidative stress.
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