Why the study?
Does diethylaminoethyl-dextran adjuvant accelerate the immune response to IVEE vaccine in rhesus monkeys?
Does diethylaminoethyl-dextran adjuvant accelerate the immune response to IVEE vaccine in rhesus monkeys?
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Diethylaminoethyl-dextran acts as an effective adjuvant for the IVEE vaccine in rhesus monkeys by accelerating the onset of IgG synthesis.
Diethylaminoethyl-dextran exhibited a significant effect on the primary immune response of rhesus monkeys to formalin-inactivated Venezuelan equine encephalomyelitis virus vaccine (IVEE). Antibody formed to IVEE and adjuvant followed a classic immunoglobulin M-immunoglobulin G pattern; however, as compared with vaccine alone, use of this adjuvant with IVEE reduced the time required for onset of immunoglobulin G synthesis.
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Houston et al. (1976) studied this question.
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