Key result
FMD vaccines with ISA 201 and 206 plus aluminum gel provide highest protection in mice.
Why the study?
Selection of adjuvants for foot-and-mouth disease vaccines requires careful evaluation to improve immunization efficacy and safety.
Combining ISA 201 or ISA 206 oil adjuvants with aluminum hydroxide gel improves protection rates against foot-and-mouth disease virus in a mouse model.
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These adjuvants merit livestock trials; animal data leave open field efficacy and translation.
Park et al. (2016) studied Foot-and-mouth disease (FMD). FMD vaccines with oil adjuvants (Emulsigen-D, ISA 201, ISA 206) mixed with aluminum hydroxide gel vs. FMD vaccines with oil adjuvants only was evaluated on Protection rate in a virus challenge test. Foot-and-mouth disease vaccines containing ISA 201 and ISA 206 mixed with aluminum hydroxide gel provided the highest protection rates in a mouse challenge model.
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