Key result
Trivalent FMD vaccine formulated with aluminum hydroxide gel, saponin, and oil induced a significantly higher antibody response (99.26% inhibition for serotype A) compared to conventional AS adjuvant (89.57%).
Why the study?
Aluminum hydroxide gel and saponin is a widely used vaccine adjuvant with poor immune response in foot-and-mouth disease vaccine, prompting evaluation of different adjuvant formulations and the effect of a booster dose.
Do different adjuvant formulations (oil based, AS with oil, or AS boosted) improve immune response to trivalent FMD vaccine in cattle compared to conventional AS adjuvant?
Do different adjuvant formulations (oil based, AS with oil, or AS boosted) improve immune response to trivalent FMD vaccine in cattle compared to conventional AS adjuvant?
Absolute Event Rate: 99.26% vs 89.57%
p-value: p=<0.05
Oil-based and AS with oil adjuvants could replace conventional aluminum hydroxide gel and saponin adjuvants to improve immune response in FMD vaccine preparations for cattle.
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Adjuvant optimization for FMD vaccines remains hypothesis-generating; randomized trials needed before practice change.
Ayele et al. (2022) studied Foot and Mouth Disease (n=29). Trivalent FMD vaccine with AS + oil adjuvant vs. Conventional AS adjuvant was evaluated on Humoral immune response (percentage of inhibition) for serotype A at 42 days post-vaccination (p=<0.05). Trivalent FMD vaccine formulated with aluminum hydroxide gel, saponin, and oil induced a significantly higher antibody response (99.26% inhibition for serotype A) compared to conventional AS adjuvant (89.57%).
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