Combined Adjuvant Formulations Enhanced an Immune Response of Trivalent Foot and Mouth Disease Vaccine in Cattle

Figures

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  Figure 1. Line graphs displaying antibody response (OD value) of individual cattle in each experimental group using Solid Phase Competitive ELISA (SPCE) (serotype (A). Control (non-vaccinated animals), Oil (animals vaccinated with oil adjuvanted vaccine), AS (animals vaccinated with aluminum hydroxide gel and saponin adjuvanted vaccine), AS boost (animals vaccinated with aluminum hydroxide gel and saponin adjuvanted vaccine and boosted), AS + Oil (animals vaccinated with Aluminum hydroxide gel, saponin and oil adjuvanted vaccine). *Booster vaccination was given on 14th day.

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  Figure 2. Line graph showing the mean antibody response of all experimental groups against serotype A at 0, 7, 14, 21, 28 and 42 days post vaccination using Solid Phase Competitive Elisa (SPCE). The blue dotted line represents control groups; the red line represents groups vaccinated with aluminum hydroxide gel and saponin adjuvanted vaccine (AS); the green dotted line represents groups vaccinated with aluminum hydroxide gel and saponin adjuvanted vaccine and boosted (AS boosted); the red dotted line represents groups vaccinated with oil adjuvanted vaccine (Oil); and the black dotted line represents groups vaccinated with aluminum hydroxide gel, saponin and oil (AS + Oil). *Booster vaccination was given on 14th day.

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  Figure 3. Line graphs displaying the antibody response (OD value) of individual animals in each group using Solid Phase Competitive ELISA (SPCE) (serotype (O). Control (non-vaccinated animals), Oil (animals vaccinated with oil adjuvanted vaccine), AS (animals vaccinated with aluminum hydroxide gel and saponin adjuvanted vaccine), AS boost (animals vaccinated with aluminum hydroxide gel and saponin adjuvanted vaccine and boosted), AS + Oil (animals vaccinated with Aluminum hydroxide gel, saponin and oil adjuvanted vaccine). *Booster vaccination was given on 14th day.

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  Figure 4. Line graph showing the mean antibody response of the groups against serotype O at 0, 7, 14, 21, 28 and 42 days post vaccination using Solid Phase Competitive ELISA (SPCE). The blue dotted line represents control groups; the red line represents groups vaccinated with aluminum hydroxide gel and saponin adjuvanted vaccine (AS); the green dotted line represents groups vaccinated with aluminum hydroxide gel and saponin adjuvanted vaccine and boosted (AS boosted); the red dotted line represents groups vaccinated with oil adjuvanted vaccine (Oil); and the black dotted line represents groups vaccinated with aluminum hydroxide gel, saponin and oil (AS+ Oil). *Booster vaccination was given on 14th day.

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  Figure 5. Line graphs displaying the antibody response of individual animals in each group using Solid Phase Competitive ELISA (SPCE) (serotype SAT 2). Control (non-vaccinated animals), Oil (animals vaccinated with oil adjuvanted vaccine), AS (animals vaccinated with aluminum hydroxide gel and saponin adjuvanted vaccine), AS boost (animals vaccinated with aluminum hydroxide gel and saponin adjuvanted vaccine and boosted), AS + Oil (animals vaccinated with Aluminum hydroxide gel, saponin and oil adjuvanted vaccine). *Booster vaccination was given on 14th day.

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  Figure 6. Line graph showing the mean antibody response of the experimental groups against serotype SAT 2 at 0, 7, 14, 21, 28 and 42 days post vaccination using Solid Phase Competitive ELISA (SPCE). The blue dotted line represents control groups; the red line represents groups vaccinated with aluminum hydroxide gel and saponin adjuvanted vaccine (AS); the green dotted line represents groups vaccinated with aluminum hydroxide gel and saponin adjuvanted vaccine and boosted (AS boosted); the red dotted line represents groups vaccinated with oil adjuvanted vaccine (Oil); and the black dotted line represents groups vaccinated with aluminum hydroxide gel, saponin and oil (AS + Oil). *Booster vaccination was given on 14th day.