Key result
FMD vaccine with ISA 201 plus aluminum hydroxide gel induces superior immunity in sheep.
Why the study?
The ideal adjuvant for foot and mouth disease vaccine that stimulates early humoral and cellular immune responses with long-lasting antibody titers is not well defined.
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May enhance FMD vaccine immunogenicity in sheep; leaves open optimal adjuvant formulation pending larger trials.
W.G. et al. (2020) studied Foot and mouth disease (FMD) (n=25). Polyvalent FMD vaccine with ISA oils and aluminum hydroxide gel vs. Vaccine with ISA oils alone or non-vaccinated control was evaluated on Cellular and humoral immune responses. Polyvalent FMD vaccine prepared with ISA 201 and aluminum hydroxide gel induced the best cellular and humoral immunity in sheep compared to other adjuvant combinations.
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