What question did this study set out to answer?

To compare the impact of moxifloxacin and clarithromycin on the composition and recovery of normal intestinal microflora.

January 1, 2000Scandinavian Journal of Infectious Diseases

Comparative Effects of Moxifloxacin and Clarithromycin on the Normal Intestinal Microflora

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To compare the impact of moxifloxacin and clarithromycin on the composition and recovery of normal intestinal microflora.
Enrolled 12 healthy male subjects (aged 24–40 years) in a crossover trial consisting of two 35-day periods separated by a 6-week washout period.
Administered 400 mg moxifloxacin once daily (with evening placebo) for 7 days in one regimen and 500 mg clarithromycin twice daily for 7 days in the other.
Moxifloxacin significantly decreased enterococci, enterobacteria, bifidobacteria, and clostridia during administration, without affecting lactobacilli, Bacteroides, or yeast.
Clarithromycin significantly reduced Escherichia coli, suppressed bifidobacteria, lactobacilli, and clostridia, and markedly increased enterococci, Enterobacter, Citrobacter, Klebsiella, and Pseudomonas.
Intestinal microflora returned to normal baseline levels in all participants by day 35 across both antibiotic regimens.

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Implication

Crossover trial demonstrates distinct temporary disruptions in gut bacterial populations from moxifloxacin and clarithromycin in healthy men, indicating full microflora recovery by day 35.

Cite This Study

G. Beyer Charlotta Edlund (2000) studied this question.

synapsesocial.com/papers/6a83127a5db41a8ba7af89ae https://doi.org/10.1080/00365540050164272

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Implication

Crossover trial demonstrates distinct temporary disruptions in gut bacterial populations from moxifloxacin and clarithromycin in healthy men, indicating full microflora recovery by day 35.

Comparative Effects of Moxifloxacin and Clarithromycin on the Normal Intestinal Microflora

Key Points

Discussion

Implication

Cite This Study

Comparative Effects of Moxifloxacin and Clarithromycin on the Normal Intestinal Microflora

Key Points

Discussion

Implication

Cite This Study

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