Key result
A 16-week walking football program was feasible and safe for men with prostate cancer on androgen deprivation therapy, improving lower body strength (p=0.035) but not significantly changing overall quality of life.
Why the study?
The feasibility and impact of a walking football program on quality of life, cardiorespiratory fitness, muscle strength, and balance in men with prostate cancer under androgen deprivation therapy remained to be determined.
Does a 16-week walking football program improve quality of life and physical fitness in men with prostate cancer undergoing androgen deprivation therapy?
RCT (n=50)
Permuted block randomization
No
Does a 16-week walking football program improve quality of life and physical fitness in men with prostate cancer undergoing androgen deprivation therapy?
Absolute Event Rate: 83.3% vs 83.3%
p-value: p=0.462
A 16-week walking football program is feasible and safe, and improves cardiorespiratory fitness and lower limb strength in prostate cancer patients on androgen deprivation therapy, though it does not significantly change overall quality of life.
Supports walking football to boost fitness during ADT; extends RCT evidence for structured exercise in prostate cancer.
Aims To analyze the feasibility and impact of a walking football (WF) program on quality of life (QoL), cardiorespiratory fitness (CRF), muscle strength, and balance program in men with prostate cancer under androgen deprivation therapy (ADT). Methods Fifty patients with prostate cancer (stages IIb-IVb) under ADT were randomized to a 16-week WF program plus usual care (n=25) or usual care control group (n=25). The WF program consisted of three 90-minute sessions per week. Recruitment, withdrawal, adherence, enjoyment rate, and safety of the intervention were recorded throughout the study. Cardiorespiratory fitness was assessed before and after the interventions, while handgrip strength, lower limb muscle strength, static balance, and QoL were assessed before, during (week 8), and after (week 16) the interventions. Adverse events during sessions were also recorded. Results The WF group showed high levels of adherence (81.6 ± 15.9%) and enjoyment rate (4.5 ± 0.5 out of 5 points). In the intention-to-treat analysis, the WF group showed an improvement in chair sit-to-stand (p=0.035) compared to the control group. Within-group comparisons showed that handgrip strength in the dominant upper limb (p=0.024), maximal isometric muscle strength in the non-dominant lower limb (p=0.006), and balance in the dominant limb (p=0.009) improved over time in the WF group but not in the usual care group. The results obtained from the per-protocol analysis indicate that CRF improved significantly in the WF group as compared to the control group ( p =0.035). Within-group analysis revealed that CRF ( p =0.036), muscle strength in dominant ( p =0.006) and non-dominant ( p =0.001) lower limbs, and balance in the non-dominant lower limb ( p =0.023) improved after 16 weeks of WF, but not in the control group. One major traumatic injury (muscle tear) was reported with a complete recovery before the end of the intervention. Conclusion This study suggests that WF is feasible, safe, and enjoyable in patients with prostate cancer under hormonal therapy. Furthermore, patients who adhere to the WF program can expect cardiorespiratory fitness, muscle strength, and balance improvements. Clinical trials registration clinicaltrials.gov, identifier NCT04062162.
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Capela et al. (2023) conducted an RCT in Prostate cancer under androgen deprivation therapy (n=50). Walking football program vs. Usual care was evaluated on Overall health-related quality of life (EORTC-QLQ-C30) (p=0.462). A 16-week walking football program was feasible and safe for men with prostate cancer on androgen deprivation therapy, improving lower body strength (p=0.035) but not significantly changing overall quality of life.
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