Key result
RV-GLPS combined with right ventricular thickness showed excellent performance for discriminating cardiac amyloidosis from hypertrophic cardiomyopathy (AUC 0.92; 95% CI 0.85-0.96; p=0.0001).
Why the study?
The study was conducted to compare right ventricular thickness and deformation between patients with cardiac amyloidosis and hypertrophic cardiomyopathy to aid in distinguishing the two conditions.
Can right ventricular thickness and deformation parameters accurately distinguish cardiac amyloidosis from hypertrophic cardiomyopathy?
Observational (n=120)
Can right ventricular thickness and deformation parameters accurately distinguish cardiac amyloidosis from hypertrophic cardiomyopathy?
Effect estimate: AUC 0.92 (95% CI 0.85-0.96)
p-value: p=0.0001
The combination of right ventricular global longitudinal peak strain and right ventricular thickness provides excellent diagnostic accuracy for distinguishing cardiac amyloidosis from hypertrophic cardiomyopathy.
May aid noninvasive differentiation of CA from HCM; leaves open prospective validation before clinical adoption.
Objectives. To compare right ventricular thickness (RVT) and deformation of cardiac amyloidosis (CA) and hypertrophic cardiomyopathy (HCM) patients. Methods. Sixty CA (mean age 58 ± 10 years; 33 males (55%)) and sixty HCM patients (mean age 55 ± 14 years; 27 males (45%)) were retrospectively enrolled. RVT, global radical peak strain (GRPS), global longitudinal peak strain (GLPS), and global circumferential peak stain (GCPS) were analyzed. To determine the cutoff values of the RVT and RV strain parameters for distinguishing CA from HCM, the areas under the receiver operating characteristic curve (AUCs) were analyzed. Results. RVT of CA patients was significantly thicker than that of HCM patients (7.8 ± 2.1 vs 5.9 ± 1.3, <a:math xmlns:a="http://www.w3.org/1998/Math/MathML" id="M1"> <a:mi>p</a:mi> </a:math> < 0.001). Moreover, significantly decreased RV-GRPS (12.1 ± 6.9 vs 23.5 ± 12.1, <c:math xmlns:c="http://www.w3.org/1998/Math/MathML" id="M2"> <c:mi>p</c:mi> </c:math> < 0.001), RV-GCPS (−3.4 ± 2.2 vs −5.6 ± 3.5, <e:math xmlns:e="http://www.w3.org/1998/Math/MathML" id="M3"> <e:mi>p</e:mi> </e:math> < 0.001), and RV-GLPS (−4.6 ± 2.3 vs −11.1 ± 4.9, <g:math xmlns:g="http://www.w3.org/1998/Math/MathML" id="M4"> <g:mi>p</g:mi> </g:math> < 0.001) were observed in CA patients compared with HCM patients. RVT and RV strain demonstrate comparable diagnostic accuracy in differentiating CA from HCM. In particular, RV-GLPS combined with RVT showed the best performance for discriminating CA from HCM (AUC = 0.92, 95% CI: 0.85 to 0.96, <i:math xmlns:i="http://www.w3.org/1998/Math/MathML" id="M5"> <i:mi>p</i:mi> </i:math> = 0.0001). Conclusions. Right ventricular myocardial thickness and deformation of CA patients was more severe than HCM patients. RV-GLPS combined with RVT presents an excellent diagnostic performance in distinguishing CA and HCM.
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Liu et al. (2022) conducted an observational in Cardiac amyloidosis and hypertrophic cardiomyopathy (n=120). Right ventricular thickness and deformation imaging was evaluated on Discrimination of cardiac amyloidosis from hypertrophic cardiomyopathy (AUC 0.92, 95% CI 0.85-0.96, p=0.0001). RV-GLPS combined with right ventricular thickness showed excellent performance for discriminating cardiac amyloidosis from hypertrophic cardiomyopathy (AUC 0.92; 95% CI 0.85-0.96; p=0.0001).
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