What question did this study set out to answer?

To determine whether in vivo hydrogen 1 (1H) MR spectroscopy, guided by dynamic contrast-enhanced MR imaging, can reliably differentiate benign from malignant musculoskeletal tumors by detecting choline.

August 1, 2004Radiology

Characterization of Bone and Soft-Tissue Tumors with in Vivo1H MR Spectroscopy: Initial Results

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Authors

CWChien‐Kuo WangNational Cheng Kung University Hospital CLChun‐Wei LiVaughn College of Aeronautics and Technology THTsyh‐Jyi Hsieh

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Implication

Diagnostic study demonstrates high accuracy of 1H MR spectroscopy in musculoskeletal tumors, indicating choline peaks reliably separate malignant from benign lesions.

Key Points

To determine whether in vivo hydrogen 1 (1H) MR spectroscopy, guided by dynamic contrast-enhanced MR imaging, can reliably differentiate benign from malignant musculoskeletal tumors by detecting choline.
Examined 36 consecutive patients with bone and soft-tissue tumors larger than 1.5 cm at 1.5 T using dynamic contrast-enhanced MR imaging to localize regions of early arterial enhancement.
Acquired single-voxel 1H MR spectroscopy with a point-resolved spectroscopic sequence at echo times of 40, 135, and 270 msec, defining choline presence as a 3.2 ppm peak in at least two spectra.
Blinded MR spectroscopic evaluations were compared against histopathologic findings using kappa statistics with significance set at P < .001.
Choline was identified in 18 of 19 malignant tumors and in 3 of 17 benign lesions (perineurioma, giant cell tumor, and abscess), while remaining undetected in 14 benign lesions and one low-grade parosteal osteosarcoma.
In vivo 1H MR spectroscopy differentiated malignant from benign lesions with a sensitivity of 95%, specificity of 82%, and overall accuracy of 89% (P < .001).

Cite This Study

Wang et al. (2004) studied this question.

synapsesocial.com/papers/6a83178095f6f1aefa9c8ea7 https://doi.org/10.1148/radiol.2322031441

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Implication

Diagnostic study demonstrates high accuracy of 1H MR spectroscopy in musculoskeletal tumors, indicating choline peaks reliably separate malignant from benign lesions.

Characterization of Bone and Soft-Tissue Tumors with in Vivo1H MR Spectroscopy: Initial Results

Discussion

Member takes

Implication

Key Points

Cite This Study

Characterization of Bone and Soft-Tissue Tumors with in Vivo1H MR Spectroscopy: Initial Results

Discussion

Member takes

Implication

Key Points

Cite This Study

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