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November 1, 1977Journal of the American Veterinary Medical Association

Encephalomyocarditis Virus Infection of Captive Elephants

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Population

8 captive African elephants from 2 widely separated zoologic gardens in Florida that died following a…

Design

Preclinical

Authors

CSCharles F. SimpsonOklahoma State UniversityALArthur L. LewisFlorida State UniversityJGJack Μ. GaskinUniversity of Florida

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Implication

EMCV identified as cause of fatal elephant disease; leaves open transmission, prevention, and zoonotic questions.

Structured PICO

P
Population
8 captive African elephants from 2 widely separated zoologic gardens in Florida that died following a fulminating illness; tissue suspensions were inoculated into newborn mice, 3- to 4-week-old mice, and buffalo green monkey and baby hamster kidney cell cultures.
I
Intervention
Inoculation of tissue suspensions from infected elephants
O
Outcome
Development of encephalitis and myocarditis in mice, destruction of cell cultures, and identification of the viral agent

Encephalomyocarditis virus was identified as the causative agent of a fulminating, fatal illness in captive African elephants.

Cite This Study

Simpson et al. (1977) studied this question.

synapsesocial.com/papers/6a8317cac4b5dbf8331f2d2fhttps://doi.org/10.2460/javma.1977.171.09.902
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1FATAL ENCEPHALOMYOCARDITIS VIRUS INFECTION IN AN AFRICAN SAVANNA ELEPHANT ( LOXODONTA AFRICANA ) IN A FRENCH ZOO2015 · 20 citations
  2. 2Encephalomyocarditis Virus in Non-Domesticated Species2025 · 5 citations
  3. 3Molecular characterization of encephalomyocarditis virus strains isolated from an African elephant and rats in a French zoo2020 · 15 citations
  4. 4Zoological transmission of encephalomyocarditis virus in the United States: Virus evolution, host ecology, and capsid antigenicity derived from an outbreak2026 · 1 citations
  5. 5An outbreak of encephalomyocarditis-virus infection in free-ranging African elephants in the Kruger National Park1995 · 64 citations