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April 18, 2025MedicineOpen Access

Surgical resection of a giant neck myxofibrosarcoma with a 1 cm negative margin, followed by chemoradiotherapy, resulted in local recurrence at 24 months and death 26 months post-recurrence.

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Why the study?

Myxofibrosarcoma is rare in the neck and characterized by a high risk of local recurrence due to its infiltrative growth pattern.

Population

A 56-year-old male with a large mass in the right neck

Design

Case report and review of the literature

Key result

Surgical resection of a giant neck myxofibrosarcoma with a 1 cm negative margin, followed by chemoradiotherapy, resulted in local recurrence at 24 months and death 26 months post-recurrence.

Authors

LZLinkun ZhongYZYing ZhangZWZhaohua Wang

Discussion

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Member takes

Overview

Poor survival after recurrence in this rare entity; leaves open effective strategies to prevent or treat local failure.

Study Design

Type

Case Report (n=1)

Structured PICO

P
Population
A 56-year-old male with a giant myxofibrosarcoma of the right neck who underwent surgical resection and adjuvant therapy, followed until death 50 months post-surgery.
I
Intervention
Surgical resection with wide margins (1 cm negative margin) along with invaded surrounding tissues, followed by radiation therapy and chemotherapy.
O
Outcome
Local recurrence and patient survivalhard clinical

Giant myxofibrosarcoma of the neck is extremely rare and challenging to treat due to its infiltrative growth pattern, requiring wide surgical margins to prevent local recurrence.

Limitations

  • Single case report limits generalizability
  • Specific margin values for giant MFS in the neck remain unconfirmed
  • Lack of effective systemic treatments for recurrent MFS

Cite This Study

Zhong et al. (2025) conducted a case report in Giant myxofibrosarcoma of neck (n=1). Surgical resection with wide margins was evaluated on Local recurrence and survival. Surgical resection of a giant neck myxofibrosarcoma with a 1 cm negative margin, followed by chemoradiotherapy, resulted in local recurrence at 24 months and death 26 months post-recurrence.

synapsesocial.com/papers/6a8317f642c9f88aa61f2fdehttps://doi.org/10.1097/md.0000000000042150
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Myxofibrosarcoma of the scalp with difficult preoperative diagnosis: A case report and review of the literature2020 · 5 citations
  2. 2Giant Myxofibrosarcoma in the Lower Limb: An Overview of Diagnostic and Clinical Management2024 · 2 citations
  3. 3Myxofibrosarcoma of the extremity and trunk2016 · 39 citations
  4. 4Myxofibrosarcoma of the Scalp: A Rare Case Report and Review of the Literature2025
  5. 5A combined, supraclavicular, infraclavicular, transaxillary, and posterior subscapular approaches for en bloc resection of giant myxofibrosarcoma2023 · 1 citations