Dynamic Nature of the Placebo Response

Traditionally, placebo has been associated with using an inert substance, in part so the subsequent response could be attributed to the target treatment, controlling for the confound of a “placebo effect.” Placebo's link with inert substances is so strong that “sham treatment” is a common synonym, and widespread placebo use is discouraged—even when there is supporting evidence for its effectiveness. Recent research has helped to redefine placebo, and this editorial will highlight key information supporting a contemporary view of placebo. J Orthop Sports Phys Ther 2010;40(8):452–454. doi:10.2519/jospt.2010.0107