Demonstrates that CaMKII can decode the frequency of intracellular calcium oscillations, providing a mechanism for frequency-dependent cellular signaling.
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May inform frequency-dependent CaMKII models in cardiomyocytes; leaves open in vivo validation and clinical relevance.
In many cell types, Ca2+ signals are organized in the form of repetitive spikes. The frequency of these intracellular Ca2+ oscillations increases with the level of stimulation, suggesting the existence of a frequency encoding phenomenon. The question arises as to how the frequency of Ca2+ oscillations can be decoded inside the cell. Ca2+/calmodulin kinase II has long been proposed as an attractive candidate, as it is a key target of Ca2+ signals. By immobilizing the Ca2+/calmodulin kinase II and subjecting it to pulses of Ca2+ of variable amplitude, duration, and frequency, De Koninck and Schulman have shown for the first time that the autonomous activity of Ca2+/calmodulin kinase II is highly sensitive to the temporal pattern of Ca2+ oscillations.
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Dupont et al. (1998) studied this question.
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