This early report describes a familial association between generalized lentigo and asymptomatic electrocardiographic abnormalities, highlighting a potential genetic syndrome.
Suggests a possible familial lentigo-ECG syndrome; hypothesis-generating and requires confirmation before any clinical screening.
THE existence of familial cardiac-conduction abnormalities has been known since a report by Morquio1 at the turn of the century. A more recent report reviewed this subject and described 3 generations of a family with conduction disorders.2 This communication reports a family of 4, 3 members of which have a pigmentary disorder attended by electrocardiographic changes, 2 having patterns resembling inferior myocardial infarction. None of the subjects have had cardiovascular symptoms at any time.The family came to our attention when the propositus, M.McD., was referred to the Pediatric Heart Clinic of the Boston City Hospital by a school physician . . .
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Walther et al. (1966) studied this question.
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