Key result
The combination of high systemic immune-inflammation index and high GRACE score strongly predicted short-term MACE in STEMI patients after PCI (HR 40.470; 95% CI 5.547-295.253).
Why the study?
Although the GRACE score and systemic immune-inflammation index independently predict adverse outcomes in STEMI, the prognostic value of combining them after PCI was evaluated.
Does the combination of GRACE risk score and systemic immune-inflammation index (SII) improve the prediction of short-term MACE in STEMI patients after PCI?
Cohort (n=1,041)
Does the combination of GRACE risk score and systemic immune-inflammation index (SII) improve the prediction of short-term MACE in STEMI patients after PCI?
Combining the GRACE risk score with the systemic immune-inflammation index significantly improves the prediction of short-term MACE in STEMI patients post-PCI.
High SII+high GRACE may flag elevated short-term MACE risk post-STEMI PCI; hypothesis-generating for improved stratification, needs prospective validation.
The Global Registry of Acute Coronary Events (GRACE) score and the systemic immune-inflammation index (SII) were used independently to predict adverse outcomes in patients with ST-elevation myocardial infarction (STEMI). In this study, 1041 patients with STEMI were divided into 4 groups based on GRACE scores and optimal cutoff values for SII. SII was positively correlated with GRACE score (r = 0.164; P < .001). SII (HR, hazard ratio: 2.051; 95%CI: 1.249–3.368; P = .005) and GRACE score (HR: 7.625; 95%CI: 3.692–15.746; P < .001) were independent risk predictors of short-term major adverse cardiovascular events (MACEs). Taking the low SII+low GRACE group as the reference group, the short-term MACE HR of the high SII+high GRACE group was 40.470 (95%CI: 5.547–295.253). Comparing the area under the curve, the combined use of SII and GRACE scores can significantly improve the prediction efficiency of short-term MACE compared with the single use of SII and GRACE scores. In conclusion, SII may be positively correlated with GRACE score, and the combination of the two accurately predicted the occurrence of short-term MACE in STEMI patients after percutaneous coronary intervention (PCI).
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Wang et al. (2023) conducted a cohort in ST-segment elevation myocardial infarction (STEMI) (n=1,041). High systemic immune-inflammation index (SII) and high GRACE score vs. Low SII and low GRACE score was evaluated on Short-term major adverse cardiovascular events (MACEs) (HR 40.470, 95% CI 5.547-295.253). The combination of high systemic immune-inflammation index and high GRACE score strongly predicted short-term MACE in STEMI patients after PCI (HR 40.470; 95% CI 5.547-295.253).
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