Key result
The GRACE risk score demonstrated good discriminatory performance (C-index = 0.86) for predicting in-hospital mortality (overall rate 3.09%) in Middle Eastern patients with acute coronary syndrome.
Why the study?
Does the GRACE risk score accurately predict in-hospital mortality in patients with acute coronary syndrome in the Arab Middle East?
Observational (n=7,709)
Yes
Does the GRACE risk score accurately predict in-hospital mortality in patients with acute coronary syndrome in the Arab Middle East?
Effect estimate: C-index 0.86
The GRACE risk score demonstrates good discriminatory performance and calibration for predicting in-hospital mortality among ACS patients in the Middle East, supporting its clinical utility in this population.
May support GRACE for ACS risk stratification in the Middle East; extends validation to this population.
Our objective was to validate the Global Registry of Acute Coronary Events (GRACE) risk score for in-hospital mortality in a Middle Eastern acute coronary syndrome (ACS) population enrolled in the Gulf Registry of Acute Coronary Events (Gulf RACE). Out of 8176, unselected, consecutive patients with ACS, during 6 months in 2006 and 2007 from 63 hospitals in 6 Arab countries in the Middle East Gulf region, 7709 (94.3%) with available data were included. The main outcome measures were discriminatory performance (using C-index) and calibration of the GRACE risk score (in-hospital mortality predicted by GRACE risk score versus the actual mortality). In-hospital mortality in the Gulf RACE was 3.09% (n = 238). The discriminatory performance of the GRACE risk scores in the Gulf RACE was good overall (C-index = 0.86). Observed and predicted risk corresponded well in each stratum of risk of in-hospital mortality. This suggests its suitability for clinical use in this patient population.
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Yusufali et al. (2011) conducted an observational in Acute Coronary Syndrome (n=7,709). GRACE risk score was evaluated on Discriminatory performance (C-index) and calibration of the GRACE risk score for in-hospital mortality (C-index 0.86). The GRACE risk score demonstrated good discriminatory performance (C-index = 0.86) for predicting in-hospital mortality (overall rate 3.09%) in Middle Eastern patients with acute coronary syndrome.
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