June 1, 1998Journal of Neuroendocrinology

Activation by Systemic Angiotensin II of Neurochemically Identified Neurons in Rat Hypothalamic Paraventricular Nucleus

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Population

Conscious rats

Comparison

Intravenous angiotensin II infusions at a rate… vs Infusions of vehicle

Design

Preclinical

Follow-up

90 min

Authors

CDCorrine A. DawsonUniversity of Alberta JJJack H. JhamandasWomen and Children’s Health Research Institute TKTeresa L. KrukoffUniversity of Alberta

Discussion

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Implication

Does not inform clinical care; leaves open whether PVN neurons mediate cardiovascular effects of circulating AII in humans.

Structured PICO

Population

Conscious rats

Intervention

Intravenous angiotensin II (AII) infusions at a rate sufficient to elevate mean arterial pressure by 40-60 mmHg for 90 min

Comparator

Infusions of vehicle

Outcome

Number of activated PVN neurons per section (measured by c-fos/FLI) and their chemical phenotypes (AT1-L, VP, OXY, NADPH-d)surrogate

Systemic angiotensin II activates specific chemically identified neurons in the rat hypothalamic paraventricular nucleus, suggesting their role in central responses to circulating AII.

Cite This Study

Dawson et al. (1998) studied this question.

synapsesocial.com/papers/6a831a5388eff2bd7befe6be https://doi.org/10.1046/j.1365-2826.1998.00225.x

Topics

Oxytocin

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Activation by Systemic Angiotensin II of Neurochemically Identified Neurons in Rat Hypothalamic Paraventricular Nucleus

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Activation by Systemic Angiotensin II of Neurochemically Identified Neurons in Rat Hypothalamic Paraventricular Nucleus

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider