Why the study?
Does central AT1 receptor antagonism lower mean arterial blood pressure in spontaneously hypertensive rats?
Population
Spontaneously hypertensive rats (SHR), including young (15-18 weeks) and old (25-29 weeks) cohorts, n=51.
Comparison
Acute intracerebroventricular injection of… vs Vehicle infusion (for chronic studies).
Design
Preclinical
Follow-up
Up to 24 hours (acute) and 4 days (chronic)
Authors
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Centrally administered AT1 antagonists likely lower MAP via peripheral blockade in SHR; leaves open central contributions to ARB effects in human hypertension.
Does central AT1 receptor antagonism lower mean arterial blood pressure in spontaneously hypertensive rats?
The hypotensive action of centrally administered AT1 receptor antagonists in spontaneously hypertensive rats is likely due to peripheral receptor blockade rather than a centrally-mediated effect.
Bunting et al. (1995) studied this question.
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