What question did this study set out to answer?

To compare overall exercise capacity and quality-of-life outcomes between rate-responsive pacing (VVIR) and fixed-rate pacing (VVI) modes.

May 1, 1991Pacing and Clinical Electrophysiology

Quality of Life in Patients with Rate Responsive Pacemakers: A Randomized, Cross‐Over Study

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Why the study?

Does VVIR pacing improve exercise capacity and quality of life compared to VVI pacing in patients with pacemakers for AV block or sick sinus syndrome?

Population

11 patients with rate responsive pacemakers implanted for complete AV block or sick sinus syndrome.

Comparison

Rate responsive pacing mode programmed for a… vs Single chamber nonrate modulated pacing mode…

Design

RCT, Randomly assigned to a cross-over study; pacemakers randomly programmed…

Follow-up

3-week study periods in each mode

Authors

MOMehmet Ali OtoMemorial Ankara Hospital HMHaldun MüderrisoğluBaşkent University MKMehmet Erdi KorkmazYıldız Technical University

Discussion

Member takes

Implication

VVIR should be preferred over VVI for better exercise capacity and QOL; confirms rate-responsive pacing benefits in this RCT.

Key Points

To compare overall exercise capacity and quality-of-life outcomes between rate-responsive pacing (VVIR) and fixed-rate pacing (VVI) modes.
Randomized crossover trial of 11 patients (7 men, 4 women; mean age 41 years, range 23–60) with complete AV block or sick sinus syndrome.
Pacemakers were randomly programmed to VVI or rate-responsive (VVIR) modes for 3-week periods in each setting.
Assessments at the end of each 3-week period included treadmill exercise testing and the Hacettepe Quality-of-Life Questionnaire.
Exercise duration was significantly longer during VVIR pacing (mean 10.54 ± 0.73 min) compared with VVI pacing (mean 7.81 ± 0.62 min; P < 0.05).
Quality-of-life scores improved significantly in VVIR mode (mean 173.81 ± 16.22 points) compared to VVI mode (mean 156.27 ± 21.22 points; P < 0.01).

Structured PICO

Does VVIR pacing improve exercise capacity and quality of life compared to VVI pacing in patients with pacemakers for AV block or sick sinus syndrome?

Population

11 patients with rate responsive pacemakers implanted for complete AV block or sick sinus syndrome (7 men, 4 women, mean age 41 years, range 23-60).

Intervention

Rate responsive (VVIR) pacing mode programmed for a 3-week study period.

Comparator

Single chamber nonrate modulated pacing (VVI) mode programmed for a 3-week study period.

Outcome

Overall exercise capacity (exercise test duration) and quality-of-life (QOL) scores evaluated by the Hacettepe Quality-of-Life Questionnaire at the end of each 3-week period.patient reported

Rate-responsive (VVIR) pacing significantly improves both exercise capacity and quality of life compared to fixed-rate (VVI) pacing in patients with AV block or sick sinus syndrome.

Cite This Study

Oto et al. (1991) studied this question.

synapsesocial.com/papers/6a831ac59080d9133c4cd912 https://doi.org/10.1111/j.1540-8159.1991.tb04110.x

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Quality of Life in Patients with Rate Responsive Pacemakers: A Randomized, Cross‐Over Study

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Quality of Life in Patients with Rate Responsive Pacemakers: A Randomized, Cross‐Over Study

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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