Key result
In rats with baroreflex failure, a bionic baroreflex system attenuated the fall in systemic arterial pressure at 10 seconds after head-up tilt from 52±5 mm Hg to 15±6 mm Hg.
Why the study?
Does a bionic baroreflex system restore arterial pressure against head-up tilt in rats with baroreflex failure?
Does a bionic baroreflex system restore arterial pressure against head-up tilt in rats with baroreflex failure?
Absolute Event Rate: 15% vs 52%
A bionic baroreflex system successfully restored arterial pressure regulation during head-up tilt in a rat model of baroreflex failure, mimicking native baroreflex function.
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May guide bionic device development; leaves open translation to human baroreflex failure.
Sato et al. (2002) studied Baroreflex failure (n=10). Bionic baroreflex system (BBS) vs. No BBS (baroreflex failure state) was evaluated on Fall in systemic arterial pressure at 10 seconds after head-up tilt. In rats with baroreflex failure, a bionic baroreflex system attenuated the fall in systemic arterial pressure at 10 seconds after head-up tilt from 52±5 mm Hg to 15±6 mm Hg.
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