Key result
Surgical excision of a misdiagnosed intra-articular synovial sarcoma in a 4-year-old boy resulted in no local recurrence or metastatic disease at 1-year follow-up.
Why the study?
Delay in diagnosis and treatment is common in synovial sarcoma cases, and tumors may be excised before the correct diagnosis is made.
Case Report (n=1)
This case highlights the importance of considering soft-tissue sarcomas like synovial sarcoma in the differential diagnosis of intra-articular knee masses in pediatric patients to avoid misdiagnosis and inappropriate management.
Supports short-term disease-free survival after resection in this rare pediatric case; leaves open need for larger series to guide protocols.
BACKGROUND: Synovial sarcoma (SS) is one of the reported sarcomas in the pediatric and adult populations. Delay in diagnosis and treatment is common in SS cases. SS may be excised before the correct diagnosis is made. CASE PRESENTATION: we present a case involving a 4-year-old boy who visited our service with complaints of left knee pain and limited knee flexion. Initially, the child was diagnosed with osteochondromatosis. Surgical excision was opted, and initial histopathological examination revealed a fibrous histiocytoma. The slide and blocks were then brought to the King Faisal Specialist Hospital Research Center (KFSH&RC) and histopathologic analysis has shown a well-circumscribed nodule in the synovium with a sub-synovial monomorphic spindle cell sarcoma, confirmed by fluorescence in situ hybridization (FISH). CONCLUSIONS: Therefore, we strongly recommend considering all differential diagnoses for soft-tissue masses when planning surgical management.
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Al-Mohrej et al. (2020) conducted a case report in Synovial sarcoma (n=1). Surgical excision was evaluated on Clinical outcome and recurrence. Surgical excision of a misdiagnosed intra-articular synovial sarcoma in a 4-year-old boy resulted in no local recurrence or metastatic disease at 1-year follow-up.
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