Key result
Primary tumors in the lungs and thorax were associated with significantly worse overall survival compared to upper limb and shoulder tumors (HR 10.021) in pediatric patients with synovial sarcoma.
Why the study?
Synovial sarcomas are aggressive soft tissue sarcomas where pediatric patients have improved outcomes compared to adults, and prognostic factors include tumor size, primary site, and distant metastases.
Population
597 pediatric (<18 years old) patients diagnosed with SS from the National Cancer Database
Comparison
Survival compared across primary anatomical sites and other prognostic variables
Design
Retrospective database cohort study
Follow-up
Up to 10 years
Authors
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Primary site informs prognosis in pediatric synovial sarcoma; leaves open prospective validation before guiding therapy.
Cohort (n=597)
Yes
Hazard Ratio: 10.021 (95% CI 4.089–24.563)
Absolute Event Rate: 50.2% vs 95.9%
p-value: p=<0.0005
In pediatric synovial sarcoma, primary anatomical site, sex, race, histology type, tumor size, and histologic grade and stage are significant prognostic variables for survival.
Curtin et al. (2019) conducted a cohort in Pediatric Synovial Sarcoma (n=597). Primary anatomical site (Lung and Thorax) vs. Upper Limb and Shoulder was evaluated on Overall survival (HR 10.021, 95% CI 4.089-24.563, p=<0.0005). Primary tumors in the lungs and thorax were associated with significantly worse overall survival compared to upper limb and shoulder tumors (HR 10.021) in pediatric patients with synovial sarcoma.
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