Why the study?
Does varying the dose of hydromorphone in demand analgesia affect patient dosing intervals following extensive surgery?
Does varying the dose of hydromorphone in demand analgesia affect patient dosing intervals following extensive surgery?
Patients using demand analgesia adapt their dosing intervals to the amount of narcotic delivered, though a minority respond to non-drug cues (placebo effect).
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Dosing intervals in postoperative demand analgesia largely track true drug effect; confirms pharmacologic dominance while isolating placebo responses to a minority subgroup.
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M. Keéri-Szántó (1979) studied this question.
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