Why the study?
What is the incidence and clinical context of arrhythmia aggravation caused by antiarrhythmic drug therapy?
What is the incidence and clinical context of arrhythmia aggravation caused by antiarrhythmic drug therapy?
Antiarrhythmic drugs carry a significant risk of aggravating arrhythmias, particularly in patients with reduced left ventricular function or a history of sustained ventricular arrhythmias, necessitating cautious use.
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Antiarrhythmic use requires vigilance for aggravation even at therapeutic levels; this review leaves open refined risk stratification in vulnerable patients.
Philip J. Podrid (1989) studied this question.
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