Key result
Early initiation of dialysis was associated with an increased risk of withdrawal from dialysis compared to late initiation (HR 1.17; 95% CI 1.06-1.30; P=0.002).
Why the study?
Does early initiation of dialysis affect the rate of withdrawal from dialysis in patients with end-stage renal disease?
Population
Patients starting dialysis between 2001 and 2009 in Canada, including those age < 75 years, age ≥ 75 years…
Comparison
Early initiation of dialysis vs Late initiation of dialysis
Design
Cohort
Follow-up
median 23.0 (IQR 34.3) months
Authors
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May warrant caution with early dialysis initiation in ESRD; leaves open causality and needs prospective confirmation.
Cohort
Yes
Does early initiation of dialysis affect the rate of withdrawal from dialysis in patients with end-stage renal disease?
Hazard Ratio: 1.17 (95% CI 1.06–1.3)
p-value: p=0.002
Early initiation of dialysis is associated with an increased risk of subsequent withdrawal from dialysis, particularly among elderly patients.
Ellwood et al. (2012) conducted a cohort in End-stage renal disease requiring dialysis. Early initiation of dialysis (eGFR > 10.5 ml/min per 1.73 m2) vs. Late initiation of dialysis (eGFR ≤ 10.5 ml/min per 1.73 m2) was evaluated on Withdrawal from dialysis (HR 1.17, 95% CI 1.06-1.30, p=0.002). Early initiation of dialysis was associated with an increased risk of withdrawal from dialysis compared to late initiation (HR 1.17; 95% CI 1.06-1.30; P=0.002).
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