Regulation of Na+-K+ Pump Activity: Pathways Between Receptors and Effectors

Short-term regulation of membrane Na+ -K+-ATPase activity is achieved by complex networks of receptor-mediated intracellular signals. Such regulatory pathways include activation of cyclic AMP-dependent protein kinase or protein kinase C and involve reversible phosphorylation of the catalytic (a) subunit of the enzyme directly, of additional mediators like eicosanoids and the actin cytoskeleton, or both.