Why the study?
Does intravenous methylprednisolone improve liver function in children with severe acute hepatitis of unknown origin?
Does intravenous methylprednisolone improve liver function in children with severe acute hepatitis of unknown origin?
Intravenous methylprednisolone may halt the progression of acute liver failure in children with severe acute hepatitis of unknown origin.
Should not yet change practice; leaves open a potential role for methylprednisolone in pediatric severe hepatitis.
Introduction: Hepatitis A is one of the most common types of viral hepatitis among children worldwide. Many infected individuals, especially younger children, are asymptomatic. It is usually transmitted by food or water contaminated with infected feces. Extra-hepatic manifestations of acute hepatitis A virus (HAV) are very rare. Case Presentation: We present a 14-year-old girl who was referred to our hospital due to jaundice, abdominal pain, weakness, and lethargy. After laboratory testing, HAV was confirmed in the patient. However, she had significant bradycardia with hypotension, which is very rare in HAV infection. Conclusions: Hepatitis A causes an acute infection. The patients usually recover after a few weeks or months. Fulminant hepatitis can be observed in HAV infection but chronic infection does not exist. Extrahepatic complications and cardiac disorders are often reported in association with hepatitis C and B viruses, but they are very rare in HAV infections.
No takes yet. Share an insight, caveat, or question.
Soleimani et al. (2015) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: