Key result
Hepatitis A virus presents significant public health risks with ~1.5 million annual cases globally.
Why the study?
Hepatitis A virus infection remains a significant public health concern and major contributor to acute viral hepatitis worldwide despite safe and effective vaccines.
Design
Review
May warrant improved pediatric HAV surveillance; leaves open true global burden despite vaccination.
Hepatitis A virus (HAV) infection remains a significant public health concern in many developing countries. The annual incidence of HAV infection is 1.5 million, though this figure may be underestimated owing to the infection’s asymptomatic nature and the presence of milder disease variants. The clinical spectrum of HAV infection now ranges from asymptomatic infection to fulminant hepatitis. Despite the availability of safe and highly effective vaccines, HAV infections remain a major contributor to acute viral hepatitis worldwide.
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Rubaiyat Alam (2025) studied this question. Hepatitis A virus infection continues to present significant public health risks with an underestimated annual incidence of 1.5 million cases globally.
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