Echovirus 6 can establish persistent infection in cloned human WISH cells, producing defective viral particles without causing cellular destruction.
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Supports non-cytopathic echovirus persistence in human cells; hypothesis-generating for chronic infection mechanisms, requires in vivo validation.
Establishment of a persistent infection by echovirus 6 in cloned human WISH cells (PI) was demonstrated. The cloned human WISH cells were maintained for 3.0 years (over 125 passages) and released virus continuously without cellular destruction. Neither temperature-sensitive virus mutants nor interferon appears to play a role in either establishment or maintenance of viral persistence. The majority of the virus produced by cloned human WISH cells is defective (2 X 10(6) particles per PFU) and differs from standard virus in its polypeptide profile and its inability to attach to parental WISH cells.
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Gibson et al. (1985) studied this question.
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