Why the study?
Does carvedilol alone or coadministered with diltiazem or prednisolone prevent doxorubicin and 5-fluorouracil-induced hepatotoxicity and nephrotoxicity in rats?
Population
140 female rats subjected to doxorubicin and 5-fluorouracil-induced toxicity models
Comparison
Carvedilol alone or coadministered with… vs Normal saline and DOX/5-FU alone
Design
Preclinical, randomly allotted into 10 groups
Follow-up
17/15 days
Authors
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Does not support clinical use; leaves open translation of rat antioxidant benefits to patients on doxorubicin/5-FU.
Does carvedilol alone or coadministered with diltiazem or prednisolone prevent doxorubicin and 5-fluorouracil-induced hepatotoxicity and nephrotoxicity in rats?
Carvedilol demonstrates protective antioxidant effects against doxorubicin and 5-fluorouracil-induced hepatotoxicity and nephrotoxicity in a rat model, with no added benefit from coadministration with diltiazem or prednisolone.
Akindele et al. (2018) studied this question.
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