Key result
Killip class III/IV linked to ~8.9-fold higher odds of in-hospital lethal arrhythmia post-AMI.
Why the study?
What are the independent predictors of in-hospital lethal arrhythmia (VT/VF) following acute myocardial infarction in patients undergoing primary PCI?
Observational (n=3,175)
Yes
What are the independent predictors of in-hospital lethal arrhythmia (VT/VF) following acute myocardial infarction in patients undergoing primary PCI?
Extensive myocardial damage, cardiogenic shock, lower initial TIMI flow, and concomitant CKD are independent predictors of in-hospital lethal arrhythmias in patients with AMI undergoing primary PCI.
Answers are grounded in this paper and cite their sources.
May inform post-PCI monitoring in high-risk AMI; leaves open whether targeted interventions reduce in-hospital arrhythmias.
Predictive factors for lethal arrhythmia after primary PCI for AMI, however, remain undetermined.In this study, we elucidated the predictors of in-hospital VT/VF events following during hospitalization for primary PCI using the Japanese registry of acute Myocardial INfarction diagnosed by Universal dEfiniTion (J-MINUET), A cute myocardial infarction (AMI) is still a lifethreating disease.1,2 Although primary percutaneous coronary intervention (PCI) is now carried out as first-line therapy, arrhythmias including ventricular tachycardia and fibrillation (VT/VF) after AMI are still lethal major complications even after successful primary PCI. 3
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Oikawa et al. (2019) conducted an observational in Acute Myocardial Infarction (n=3,175). Killip class III or IV vs. Killip class I or II was evaluated on In-hospital VT/VF (hemodynamically unstable VT or VF in the first week of hospitalization) (adjusted OR 8.93, 95% CI 5.668-14.082, p=<0.0001). Killip class III or IV (adjusted OR 8.93), maximum CK >3000 IU/L, initial TIMI flow grade 0/1, and chronic kidney disease independently predicted in-hospital lethal arrhythmia after AMI.
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