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In a study of the basal excretion patterns of total urinary estrogens and luteinizing hormone (LH) 106 cases of secondary amenorrhea caused by various conditions (29% psychiatric) were hospitalized and 24-hour urine samples were measured for a minimum of 6 days. When plotted the variations in LH and estrogen formed a biphasic pattern with peaks at 50 U/24 hours and 110 U/24 hours. 58 women had a mean LH below 50 U/24 hours which was higher than the mean value for normal menstruating women. 83 women showed an estrogen level below 15 mcg/24 hours. A heterogeneous sample of 7 women with primary amenorrhea was similarly investigated and no pattern for the levels of LH and estrogens was found.
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Richard Newton (1972) studied this question.
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