Why the study?
Do COX-2-derived prostaglandins stimulate the expression of thrombomodulin in human vascular smooth muscle cells?
Population
Cultured human coronary artery smooth muscle cells
Design
Preclinical
Authors
Loading...
May explain prothrombotic effects of COX-2 inhibitors via thrombomodulin; leaves open clinical relevance pending in vivo confirmation.
Do COX-2-derived prostaglandins stimulate the expression of thrombomodulin in human vascular smooth muscle cells?
The finding that COX-2-derived prostaglandins stimulate thrombomodulin expression provides a novel platelet-independent mechanism explaining the prothrombotic effects of COX-2 inhibitors.
Rabausch et al. (2005) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: