Soluble S antigen is responsible for nuclear fluorescence and cross-staining reactions among influenza A strains in infected ferret respiratory epithelial cells.
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Attributes nuclear fluorescence and cross-staining to S antigen in influenza A; leaves open translation to human diagnostics or vaccines.
Yellow-green fluorescence representing viral antigens was detected in both the nucleus and cytoplasm of epithelial cells of the respiratory tract in ferrets infected with influenza virus. This nuclear fluorescence was the chief manifestation of cross-fluorescent staining reactions among three strains of influenza A virus studied, PR8, Farrington, and Fm(1). Absorption experiments with influenza viral V and soluble S antigens showed that S antigen was responsible for the presence of fluorescence in the nucleus and for the cross-staining reactions among these strains.
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Ch'ien Liu (1955) studied this question.
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