August 1, 1986Annals of Internal Medicine
Serum Enzyme Assays in the Diagnosis of Acute Myocardial Infarction Recommendations Based on a Quantitative Analysis
Why the study?
Do serum enzyme assays accurately diagnose acute myocardial infarction in suspected patients?
Population
Patients suspected of having acute myocardial infarction
Design
Review
Authors
Discussion
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Member takes
Implication
Reinforces serial testing to exclude MI; leaves open whether high-sensitivity troponin alters this approach.
Structured PICO
Do serum enzyme assays accurately diagnose acute myocardial infarction in suspected patients?
P
Population
Patients suspected of having acute myocardial infarction
I
Intervention
Serum enzyme assays (creatine kinase, CK-MB, lactate dehydrogenase isoenzymes)
O
Outcome
Diagnosis of acute myocardial infarction
Serial measurements of cardiac enzymes (CK, CK-MB) at admission, 12, and 24 hours are necessary for accurate diagnosis of acute myocardial infarction due to the poor sensitivity of single measurements.
Cite This Study
Thomas H. Lee (1986) studied this question.