Pulmonary Alveolar Proteinosis

Article1 February 1965Pulmonary Alveolar ProteinosisReport of Six Cases, Review of the Literature, and Formulation of a New TheoryROGER K. LARSON, M.D., F.A.C.P., RICHARD GORDINIER, M.D.ROGER K. LARSON, M.D., F.A.C.P.Search for more papers by this author, RICHARD GORDINIER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-2-292 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptBeginning with the initial description by Rosen, Castleman, and Liebow (1), a total of 79 cases of pulmonary alveolar proteinosis has been recorded in the medical literature (1-51). It is the purpose of this paper to add 6 new cases, to summarize the clinical features of all 85 cases, and to formulate a new theory about the origin of the intra-alveolar material that is so characteristic of the disease. Eighty-four of these 85 cases were confirmed by histological examination. One diagnosis was based on sputum examination only (25).CASE STUDIESCASE 1W. H., a 38-year-old Caucasian male police officer,...References1. ROSENCASTLEMANLIEBOW SHBAA: Pulmonary alveolar proteinosis. New Eng. J. Med. 258: 1123, 1958. CrossrefMedlineGoogle Scholar2. LEVINSONJONESWINTROBECARTWRIGHT BRSMMGE: Thrombocythemia and pulmonary intra-alveolar coagulum in a young woman. Blood 13: 959, 1958. CrossrefMedlineGoogle Scholar3. FRIEDMANSTRICKLAND BCE: Pulmonary alveolar proteinosis. J. Tenn. Med. Ass. 51: 507, 1958. Google Scholar4. SCHOENREINGOLDMEISTER IIML: Relapsing nodular nonsuppurative panniculitis with lung involvement: clinical and autopsy findings with notes on pathogenesis. Ann. Intern. Med. 49: 687, 1958. LinkGoogle Scholar5. PAYSEURKONWALERHYDE CRBEL: Pulmonary alveolar proteinosis. A progressive, diffuse, fatal pulmonary disease. Amer. Rev. Tuberc. 78: 906, 1958. Google Scholar6. 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LARSON, M.D., F.A.C.P.; RICHARD GORDINIER, M.D.Affiliations: Fresno and Los Angeles, CaliforniaFrom the Department of Medicine, Fresno County General Hospital, Fresno, Calif., and the Department of Medicine, University of California Medical Center, Los Angeles, Calif.Requests for reprints should be addressed to Roger K. Larson, M.D., Fresno County General Hospital, 445 S. Cedar Ave., Fresno, Calif. 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