September 1, 1992Bulletin of the Chemical Society of Japan50 citations

An Efficient and Practical Synthesis of l-α-Amino Acids Using (R)-Phenylglycinol as a Chiral Auxiliary

TITakashi Inaba IKIchiro Kozono MFMakoto Fujita

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Abstract

Abstract l-α-Amino acids including l-α-arylglycines were conveniently and stereoselectively synthesized via the α-amino carbonitriles given by the Strecker reaction of (R)-2-amino-2-phenylethanol with aldehydes and hydrogen cyanide. The stereoselectivity of these α-amino carbonitriles was thermodynamically controlled.

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Inaba et al. (1992) studied this question.

synapsesocial.com/papers/6a8330ce567e1954e7efdbe6 https://doi.org/10.1246/bcsj.65.2359

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