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August 14, 1997New England Journal of MedicineOpen Access

Origin of Nodular Lymphocyte-Predominant Hodgkin's Disease from a Clonal Expansion of Highly Mutated Germinal-Center B Cells

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Authors

TMTheresa MarafiotiUniversity of PerugiaMHMichael HummelHumboldt-Universität zu BerlinIAIoannis AnagnostopoulosFreie Universität Berlin

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Marafioti et al. (1997) studied this question.

synapsesocial.com/papers/6a83318fa353bb944193d3a6https://doi.org/10.1056/nejm199708143370703
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The expression of the B‐cell marker mb‐1 (CD79a) in Hodgkin's disease1994 · 63 citations
  2. 2Combination of Hodgkin's disease and diffuse large cell lymphoma: an in situ hybridization study for immunoglobulin light chain messenger RNA1995 · 13 citations
  3. 3Oligonucleotide primers for polymerase chain reaction amplification of human immunoglobulin variable genes and design of family‐specific oligonucleotide probes1991 · 214 citations
  4. 4Hodgkin and Reed-Sternberg cells in Hodgkin's disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells.1996 · 759 citations
  5. 5Hodgkin's disease with a B-cell phenotype often shows a VDJ rearrangement and somatic mutations in the VH genes1994 · 118 citations