Why the study?
Birth involves substantial shifts in cardiovascular physiology, but little is known about coronary vascular adaptations during this period.
Does the birth transition alter coronary conductance and myocardial perfusion in sheep?
Does the birth transition alter coronary conductance and myocardial perfusion in sheep?
Cardiac growth outpaces coronary microvascular growth during the immediate perinatal period, resulting in lower capacity for microvascular perfusion in the early neonate compared to the late-gestation fetus.
No takes yet. Share an insight, caveat, or question.
Lower neonatal coronary conductance in sheep is hypothesis-generating; human perinatal microvascular studies needed before clinical consideration.
Hagen et al. (2022) studied this question.
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