What question did this study set out to answer?

To review and summarize recent advances regarding the roles, interactions, and cellular mechanisms of various immunocyte subsets in the progression of systemic lupus erythematosus.

September 13, 2021Open Access

Cellular Mechanism of Immunology in Systemic Lupus Erythematosus

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Authors

TXTianhong XieNagasaki University PLPing Li

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Implication

Review details mechanisms of autoantibody production in lupus, highlighting the roles of autoreactive T cells and regulatory cell defects.

Key Points

To review and summarize recent advances regarding the roles, interactions, and cellular mechanisms of various immunocyte subsets in the progression of systemic lupus erythematosus.
Narrative synthesis of recent immunological literature investigating murine models and cellular pathways in systemic lupus erythematosus.
Evaluation of mechanistic evidence covering CD138+ and double-negative T cells, regulatory B cells, and myeloid-derived suppressor cells.
CD138 expression in CD3+ T cells prevents apoptosis in autoreactive populations, including double-negative T cells, fostering their accumulation and enhancing autoantibody production.
Persistent inflammatory cytokine elevation drives myeloid-derived suppressor cells to differentiate into macrophages and dendritic cells instead of supporting regulatory B-cell expansion, which disrupts immune tolerance and promotes plasma cell antibody secretion.

Cite This Study

Xie et al. (2021) studied this question.

synapsesocial.com/papers/6a8333336f989a47dda5095a https://doi.org/10.22541/au.163155174.43902522/v1

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Implication

Review details mechanisms of autoantibody production in lupus, highlighting the roles of autoreactive T cells and regulatory cell defects.

Cellular Mechanism of Immunology in Systemic Lupus Erythematosus

Discussion

Member takes

Implication

Key Points

Cite This Study

Cellular Mechanism of Immunology in Systemic Lupus Erythematosus

Discussion

Member takes

Implication

Key Points

Cite This Study

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