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January 1, 1999European Heart JournalOpen Access

Cardioprotection by opening of the KATPchannel in unstable angina Is this a clinical manifestation of myocardial preconditioning? Results of a randomized study with nicorandil

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Why the study?

Does oral nicorandil reduce transient myocardial ischaemia and tachyarrhythmia in patients with unstable angina?

Population

245 patients admitted with unstable angina.

Comparison

Oral nicorandil 20 mg twice daily for a minimum… vs Matching placebo added to standardized treatment.

Design

RCT, randomized, parallel-group, double-blind, placebo-controlled

Follow-up

48 h

Authors

DPDeven PatelJohns Hopkins Hospital

Discussion

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Implication

Supports nicorandil addition to standard therapy in unstable angina; reinforces RCT evidence for fewer ischemic and arrhythmic events.

Structured PICO

Does oral nicorandil reduce transient myocardial ischaemia and tachyarrhythmia in patients with unstable angina?

P
Population
245 patients admitted with unstable angina (excluding those with myocardial infarction identified retrospectively from troponin-T analysis).
I
Intervention
Oral nicorandil 20 mg twice daily for a minimum of 48 h, added to standardized treatment (oral aspirin, a beta-blocker, and diltiazem where tolerated).
C
Comparator
Matching placebo added to standardized treatment (oral aspirin, a beta-blocker, and diltiazem where tolerated).
O
Outcome
Frequency and duration of transient myocardial ischaemia and any tachyarrhythmia assessed by continuous Holter ECG monitoring for 48 h.surrogate

Nicorandil added to standard anti-anginal therapy reduces transient myocardial ischemia and arrhythmias in patients with unstable angina.

Cite This Study

Deven Patel (1999) studied this question.

synapsesocial.com/papers/6a83333fb9768edacab38195https://doi.org/10.1053/euhj.1998.1354

Topics

Women and heart disease
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Protective effects of preconditioning of the ischaemic myocardium involve cyclo-oxygenase products1990 · 148 citations
  2. 2Role of ATP sensitive potassium channel in extracellular potassium accumulation and cardiac arrhythmias during myocardial ischaemia1994 · 82 citations
  3. 3Does Ischemic Preconditioning in the Human Involve Protein Kinase C and the ATP-Dependent K<sup>+</sup>Channel?1995 · 291 citations
  4. 4One-year results of the thrombolysis in myocardial infarction (TIMI) IIIB clinical trial1995 · 342 citations