Population
Xenopus oocytes expressing cloned inward rectifier channels (KIR1.1, KIR2.1, or KIR2.3)
Comparison
Protein kinase A activators, protein kinase C… vs Inactive phorbol ester or baseline conditions
Design
Preclinical
Authors
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Selective Kir2.3 inhibition by PKC may underlie tissue-specific responses; leaves open in vivo cardiovascular translation.
KIR2.3 channels, unlike KIR1.1 and KIR2.1, are specifically regulated by PKC activation and low extracellular sodium, which may explain tissue-specific responses to PKC stimulation.
Henry et al. (1996) studied this question.
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