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The hydrochloride of ethyl p-aminobenzoate was synthesized and its anesthetic potency compared with that of MS-222 at concentrations of 50,80, and 100 mg/L. The free compound of these agents in fish blood was also determined. The results indicate that benzocaine hydrochloride is a more effective anesthetic than MS-222 at the concentrations applied. It must be pointed out, however, that benzocaine hydrochloride is not registered for fishery use in the United States.
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Ferreira et al. (1979) studied this question.
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